Pediatric autoimmune encephalitis: Recognition and diagnosis
| Autor: | Maarten J. Titulaer, Anna E M Bastiaansen, Peter A. E. Sillevis Smitt, Rogier Q. Hintzen, Arlette L. Bruijstens, Agnes van Sonderen, Marco W.J. Schreurs, Rinze F. Neuteboom, Marienke A.A.M. de Bruijn |
|---|---|
| Přispěvatelé: | Neurology, Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Encephalopathy Article Cohort Studies Autoimmune Diseases of the Nervous System medicine Humans Child Netherlands Anti-N-Methyl-D-Aspartate Receptor Encephalitis Autoimmune encephalitis business.industry Incidence (epidemiology) Encephalomyelitis Acute Disseminated Infant Guideline medicine.disease Neurology Child Preschool Practice Guidelines as Topic Acute disseminated encephalomyelitis Etiology Encephalitis Female Neurology (clinical) business Cohort study |
| Zdroj: | Neurology(R) neuroimmunology & neuroinflammation, 7. Lippincott Williams & Wilkins Neurology® Neuroimmunology & Neuroinflammation |
| ISSN: | 2332-7812 |
| Popis: | ObjectiveThe aims of this study were (1) to describe the incidence of autoimmune encephalitis (AIE) and acute disseminated encephalomyelitis (ADEM) in children, (2) to validate the currently used clinical criteria to diagnose AIE, and (3) to describe pitfalls in the diagnosis of pediatric autoimmune (AI) and inflammatory neurologic disorders.MethodsThis study cohort consists of 3 patient categories: (1) children with antibody-mediated AIE (n = 21), (2) children with ADEM (n = 32), and (3) children with suspicion of an AI etiology of their neurologic symptoms (n = 60). Baseline and follow-up clinical data were used to validate the current guideline to diagnose AIE. In addition, patient files and final diagnoses were reviewed.ResultsOne-hundred three of the 113 included patients fulfilled the criteria of possible AIE. Twenty-one children had antibody-mediated AIE, of whom 19 had anti-N-methyl-D-aspartate receptor (NMDAR), 1 had anti–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, and 1 had anti–leucine-rich glioma-inactivated protein 1 encephalitis. Finally, 34 children had ADEM, and 2 children had Hashimoto encephalopathy. Mean incidence rates were 1.54 children/million (95% CI 0.95–2.35) for antibody-mediated AIE and 2.49 children/million (95% CI 1.73–3.48) for ADEM. Of the other 48 children, treating physicians' diagnoses were reviewed. In 22% (n = 6) of children initially diagnosed as having an AI/inflammatory etiology (n = 27), no support for AI/inflammation was found.ConclusionBesides anti-NMDAR encephalitis and ADEM, other AIEs are rare in children. The current guideline to diagnose AIE is also useful in children. However, in children with nonspecific symptoms, it is important to review data critically, to perform complete workup, and to consult specialized neuroinflammatory centers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|