In silico analysis of different generation β lactams antibiotics with penicillin binding protein-2 of Neisseria meningitidis for curing meningococcal disease
| Autor: | Pooja Tripathi, Vijay Tripathi, Navita Srivastava, Dwijendra K. Gupta |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Penicillin binding proteins medicine.drug_class Antibiotics Molecular Sequence Data Ceftazidime Sequence Homology Health Informatics Microbial Sensitivity Tests Penicillins Neisseria meningitidis medicine.disease_cause Meningococcal disease beta-Lactams Models Biological General Biochemistry Genetics and Molecular Biology Microbiology Antibiotic resistance Bacterial Proteins Cell Wall polycyclic compounds medicine Humans Penicillin-Binding Proteins Computer Simulation Amino Acid Sequence Chemistry Drug Resistance Microbial medicine.disease Virology Computer Science Applications Anti-Bacterial Agents Penicillin Meningococcal Infections Penicillin binding medicine.drug Protein Binding |
| Zdroj: | Interdisciplinary sciences, computational life sciences. 6(4) |
| ISSN: | 1867-1462 |
| Popis: | Neisseria meningitidis is a gram negative, diplococcic pathogen responsible for the meningococcal disease and fulminant septicemia. Penicillin-binding proteins-2 (PBPs) is crucial for the cell wall biosynthesis during cell proliferation of N. meningitidis and these are the target for β-lactam antibiotics. For many years penicillin has been recognized as the antibiotic for meningococcal disease but the meningococcus has seemed to be antibiotic resistance. In the present work we have verified the molecular interaction of Penicillin binding protein-2 N. meningitidis to different generation of β-lactam antibiotics and concluded that the third generation of β-lactam antibiotics shows efficient binding with Penicillin binding protein-2 of N. meningitidis. On the basis of binding efficiency and inhibition constant, ceftazidime emerged as the most efficient antibiotic amongst the other advanced β-lactam antibiotics against Penicillin-binding protein-2 of N. meningitidis. |
| Databáze: | OpenAIRE |
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