Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children
| Autor: | Natalia Chislovska, Joseph Nakonechny, Zoreslava Shkiryak-Nyzhnyk, Alexander Zvinchuk, Peter A. Scheff, Amy P. Mucha, Elena Lukyanova, Andrij Serdyuk, Daniel O. Hryhorczuk, Motria Caudill, Serap Erdal |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
1-hydroxypyrene Health Toxicology and Mutagenesis Urinary system air pollution polycyclic aromatic hydrocarbons 010501 environmental sciences 01 natural sciences Tobacco smoke Toxicology 03 medical and health sciences chemistry.chemical_compound children Environmental health Humans Polycyclic Compounds 030304 developmental biology 0105 earth and related environmental sciences 2. Zero hunger 0303 health sciences Creatinine Pyrenes Research Public Health Environmental and Occupational Health Environmental exposure Environmental Exposure Pah exposure 3. Good health Epidemiologic Studies chemistry Child Preschool Capital city Children's Health Biomarker (medicine) biomarker Biological Markers Female environment Biomarkers |
| Zdroj: | Environmental Health Perspectives |
| Popis: | Biomarkers of exposure & early effects: field studiesBiomarker: 1-hydroxypyrene (1-OHP)Exposure/effect represented: PAHStudy design: cross-sectionalStudy size: 48 children from Mariupol and 42 children from KievAnalytical technique: reverse-phase high-performance liquid chromatography with enzymatic hydrolysis using β- glucuronidase/arylsulfataseTissue/biological material/sample size: urineHalf-life of biomarker: 9.8 hrSurrogate/target tissue relationship: goodRelationship with exposure or effect of interest (including dose-response): 0.69ngr/ml in Mariupol vs 0.34ngr/ml in Kiev, p= 0.0001Factors modulating biomarkers: ETS Keywords classification: analysis;biomarkers of exposure & effect: field studies;Biological Markers;Child,Preschool;Environmental Exposure;Epidemiologic Studies;Female;Humans;Male;Polycyclic Compounds;Public Health;Pyrenes;Research;Safety;urine;Ukraine; Urinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted: 0.69 vs. 0.34 micromol/mol creatinine, p < 0.001; unadjusted: 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 micromol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs. |
| Databáze: | OpenAIRE |
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