Mitochondrial adventures at the organelle society
| Autor: | F Tiago Branco, King Faisal Yambire, Lorena Fernández Mosquera, Cátia V. Diogo, Nuno Raimundo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mitochondrial Diseases Transcription Genetic Biophysics AMP-Activated Protein Kinases Mitochondrion Biology Endoplasmic Reticulum Biochemistry Article 03 medical and health sciences Organelle Peroxisomes Animals Humans Zellweger Syndrome Molecular Biology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Endoplasmic reticulum Cell Biology Peroxisome Mitochondria Cell biology Lysosomal Storage Diseases Crosstalk (biology) 030104 developmental biology Gene Expression Regulation mitochondrial fusion Organelle biogenesis Lysosomes Biogenesis Signal Transduction |
| Zdroj: | Biochemical and Biophysical Research Communications |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2017.04.124 |
| Popis: | Mitochondria are constantly communicating with the rest of the cell. Defects in mitochondria underlie severe pathologies, whose mechanisms remain poorly understood. It is becoming increasingly evident that mitochondrial malfunction resonates in other organelles, perturbing their function and their biogenesis. In this manuscript, we review the current knowledge on the cross-talk between mitochondria and other organelles, particularly lysosomes, peroxisomes and the endoplasmic reticulum. Several organelle interactions are mediated by transcriptional programs, and other signaling mechanisms are likely mediating organelle dysfunction downstream of mitochondrial impairments. Many of these organelle crosstalk pathways are likely to have a role in pathological processes. Highlights • Mitochondrial malfunction affects lysosomal biogenesis via AMPK signaling. • Lysosomal malfunction represses mitochondrial function. • ER stress promotes degradation of damaged mitochondria. • Organelle crosstalk is a key component of mitochondrial signaling in physiology and pathology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect