Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
| Autor: | Monica C. Botelho, Rúben Fernandes, Rita Cardoso, Katia C. Oliveira, Antonio C. Dos Santos |
|---|---|
| Přispěvatelé: | Repositório Científico do Instituto Politécnico do Porto |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Infertility Schistosoma mansoni infection Endocrinology Diabetes and Metabolism medicine.medical_treatment Physiology Schistosomiasis Steroid 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Immunology and Allergy Endocrine system Testosterone Host-parasite interaction Progesterone Steroid hormones Schistosoma haematobium 030219 obstetrics & reproductive medicine biology Estradiol biology.organism_classification medicine.disease 3. Good health 030104 developmental biology Schistosoma mansoni Hormone |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. This work was supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo – Grant 2012/50115-6) and FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER- 007274), and by UID/BIM/04293/2013. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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