Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
| Autor: | J. Kupusarevic, Davina Camargo Madeira Simoes, Matthew Furber, Thomas W. Jones, Lee Eddens, Glyn Howatson, K. A. van Someren |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Anabolism Physiology Science AMP-Activated Protein Kinases 030204 cardiovascular system & hematology Affect (psychology) Article 03 medical and health sciences 0302 clinical medicine Endurance training Internal medicine Humans Medicine Aerobic exercise Phosphorylation Muscle Skeletal Exercise Cross-Over Studies Multidisciplinary biology business.industry Athletes TOR Serine-Threonine Kinases Resistance training AMPK Resistance Training biology.organism_classification C600 Intensity (physics) Endurance Training Endocrinology business Biomarkers 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | This study examined whether intensity of endurance stimulus within a concurrent training paradigm influenced the phosphorylation of signaling proteins associated with the mTOR and AMPK networks. Eight male cyclists completed (1) resistance exercise (RES), 6 × 8 squats at 80% 1-RM; (2) resistance exercise and moderate intensity cycling of 40 min at 65% V̇O2peak, (RES + MIC); (3) resistance exercise and high intensity interval cycling of 40 min with 6 alternating 3 min intervals of 85 and 45% V̇O2peak (RES + HIIC), in a cross-over design. Muscle biopsies were collected at rest and 3 h post-RES. There was a main effect of condition for mTORS2448 (p = 0.043), with a greater response in the RES + MIC relative to RES condition (p = 0.033). There was a main effect of condition for AMPKα2T172 (p = 0.041), with a greater response in RES + MIC, relative to both RES + HIIC (p = 0.026) and RES (p = 0.046). There were no other condition effects for the remaining protein kinases assessed (p > 0.05). These data do not support a molecular interference effect in cyclists under controlled conditions. There was no intensity-dependent regulation of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise intensity. |
| Databáze: | OpenAIRE |
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