Development and validation of a scoring index to predict the presence of lesions in capsule endoscopy in patients with suspected Crohn’s disease of the small bowel
Autor: | Pilar Borque Barrera, Marisol Luján-Sanchis, Begoña Gonzalez Suarez, Vicente Pons Beltrán, Joaquín Sánchez Cuenca, César Prieto de Frías, Fernando Alberca de Las Parras, José Francisco Juanmartiñena Fernández, Enrique Pérez-Cuadrado Robles, Julio Valle Muñoz, Noelia Alonso Lázaro, Blanca Martínez Andrés, Fernando Carballo Álvarez, Cristian Sierra Bernal, Violeta María Sastre Lozano, Carolina Torres González, Cristina Rodríguez de Miguel, Juan Egea-Valenzuela, Ignacio Fernández-Urién Sainz, Cristina Carretero Ribón, Mileidis San Juan Acosta, Félix de Vera Almenar, Pilar Martínez García |
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Rok vydání: | 2018 |
Předmět: |
Male
capsule endoscopy Disease Capsule Endoscopy law.invention Feces 0302 clinical medicine Crohn Disease law small bowel Intestine Small Medicine 030212 general & internal medicine Young adult Child Aged 80 and over education.field_of_study Crohn's disease Gastroenterology Middle Aged C-Reactive Protein Child Preschool Predictive value of tests Biomarker (medicine) Female 030211 gastroenterology & hepatology Adult medicine.medical_specialty Adolescent Population Risk Assessment Sensitivity and Specificity Young Adult 03 medical and health sciences Predictive Value of Tests Capsule endoscopy Internal medicine Humans education Aged Hepatology business.industry biomarkers Reproducibility of Results medicine.disease digestive system diseases Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
Zdroj: | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
ISSN: | 0954-691X |
DOI: | 10.1097/meg.0000000000001083 |
Popis: | Background Capsule endoscopy (CE) is the first-line investigation in cases of suspected Crohn's disease (CD) of the small bowel, but the factors associated with a higher diagnostic yield remain unclear. Objective Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers. Patients and methods Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index. This was first used on this population (internal validation process) and after that on a different set of patients from a multicenter study (external validation process). Results An index was designed in which every biomarker is assigned a score. Three risk groups have been established (low, intermediate, and high). In the internal validation analysis (124 individuals), patients had a 10, 46.5, and 81% probability of showing inflammatory lesions in CE in the low-risk, intermediate-risk, and high-risk groups, respectively. In the external validation analysis, including 410 patients from 12 Spanish hospitals, this probability was 15.8, 49.7, and 80.6% for the low-risk, intermediate-risk, and high-risk groups, respectively. Conclusion Results from the internal validation process show that the scoring index is coherent, and results from the external validation process confirm its reliability. This index can be a useful tool for selecting patients before CE studies in cases of suspected CD of the small bowel. |
Databáze: | OpenAIRE |
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