| Autor: |
Zhang, Tian, Zheng, Qiang, Fu, Yike, Xie, Congkun, Fan, Gonglin, Wang, Yifan, Wu, Yongjun, Cai, Xiujun, Han, Gaorong, Li, Xiang |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.16935740 |
| Popis: |
Additional file 1: Figure S1. SEM images of (a) Fe2O3 and (b) FP NPs. Figure S2. Colloidal stability of FP NPs. (a) Tyndall effect of Fe2O3 (left) and FP NPs (right). (b) DLS profiles and the optical images of FP NPs in water, PBS and serum (from left to right) after 4 h. Figure S3. The FTIR spectra of mPEG-SH, FP NPs and FP NPs modified with mPEG-SH. Figure S4. The UV���vis spectra of time-dependent DPBF degradation after incubation with (a) blank, (b) Fe2O3, (c) FP + H2O2 (200 ��M) under US irradiation (1.0 MHZ, 1.0 W cm���2). Figure S5. The solid UV���vis spectra of Fe2O3 and FP NPs. Figure S6. TEM image of pure Pt NPs with the same size as that on the surface of FP NPs. Figure S7. ROS fluorescence intensity of 4T1 cells by flow cytometry analysis after incubation with FP NPs under different conditions. Figure S8. The fluorescence images of 4T1 cells staining with DCFH-DA, calcein AM (green, live cells)/ PI (red, dead cells) and RDPP after different treatments. Figure S9. (a) The optical images of O2 generation after incubation with H2O2 (100 mM), FP NPs and FP + H2O2 (100 mM) for 5 min. (b) In vivo US imaging and time-intensity curve analysis of contrast-enhanced ultrasound imaging after intratumoral injection of FP NPs. Figure S10. The representative mice photographs of each groups recorded every 2 days. Figure S11. The immunohistochemistry detection for HIF-1�� of tumor tissues from the mice in different groups. Figure S12. Routine blood analysis including mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH). Figure S13. H&E staining of the major organs (heart, liver, spleen, lung and kidney) of mice to examine the pathological changes treated with FP, Fe2O3 + US, Pt + US and Fe2O3/Pt + US. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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