Serum betatrophin levels are significantly increased in obese patients compared to lean patients regardless to the presence of PCOS

Autor:	Betul Keyif, Ozguc Takmaz, Faruk Buyru, Hale Goksever Celik, Merve Mehves Celebi, Burcin Karamustafaoglu Balci, Ercan Bastu, Selin Ozaltin
Rok vydání:	2020
Předmět:	Adult medicine.medical_specialty endocrine system diseases Betatrophin Peptide Hormones Endocrinology Diabetes and Metabolism Adipose tissue 030209 endocrinology & metabolism Carbohydrate metabolism Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Thinness Angiopoietin-Like Protein 8 Internal medicine medicine Humans In patient Obesity 030219 obstetrics & reproductive medicine biology business.industry Obstetrics and Gynecology medicine.disease Polycystic ovary Angiopoietin-like Proteins Case-Control Studies biology.protein Female Insulin Resistance business Polycystic Ovary Syndrome
Zdroj:	Gynecological Endocrinology. 36:678-681
ISSN:	1473-0766 0951-3590
Popis:	Betatrophin, which regulates glucose metabolism, is primarily expressed in liver and fat tissue. We aimed to investigate betatrophin levels in patients with polycystic ovary syndrome (PCOS) that is the most common endocrine pathology in women of reproductive age. A total of 69 women were included in this prospective study: 35 patients with PCOS (18 obese and 17 lean) and 34 healthy controls (17 obese and 17 lean). Patients who met the criteria were compared regarding betatrophin levels and other hormonal values. Serum betatrophin level did not differ between obese PCOS patients and obese controls, and lean PCOS patients and lean controls; while significantly increased in obese PCOS patients and controls compared to lean PCOS patients and controls. Total testosterone and androstenedione were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while sex hormone-binding globulin was significantly lower in patients with PCOS than in controls both in the obese and lean groups. However, remaining hormone values were similar between groups. Betatrophin level was significantly increased in obese patients compared to lean patients independent to the presence of PCOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc93dd298338d77a37f12349b64941d https://doi.org/10.1080/09513590.2020.1725964 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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