Time-Dependent Effect of Tamoxifen Therapy on Endometrial Pathology in Asymptomatic Postmenopausal Breast Cancer Patients
| Autor: | Jeremiah Shapira, Ronnie Tepper, Yoram Beyth, Marco M. Altaras, Y. Zalel, Arie Figer, Dror Yigael, Ilan Cohen, Doron J.D. Rosen, Mario Cordoba |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Antineoplastic Agents Hormonal Biopsy Mammary gland Breast Neoplasms Asymptomatic Drug Administration Schedule Pathology and Forensic Medicine Endometrium Breast cancer Risk Factors Endometrial Polyp Carcinoma Humans Medicine Prospective Studies Prospective cohort study Retrospective Studies Analysis of Variance Estradiol business.industry Obstetrics and Gynecology Middle Aged medicine.disease Endometrial Neoplasms Endometrial hyperplasia Postmenopause Tamoxifen Cross-Sectional Studies medicine.anatomical_structure Endometrial Hyperplasia Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | International Journal of Gynecological Pathology. 15:152-157 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/00004347-199604000-00010 |
| Popis: | Various endometrial lesions were more frequent among asymptomatic postmenopausal breast cancer patients who were treated with tamoxifen for > 48 consecutive months (30.8%) when compared with similar patients who were treated for 6-24 months or for 25-48 months (20.8% and 12.5%, respectively). However, this difference was not statistically significant. There were also no significant differences in the frequency of the various endometrial lesions between these three groups, although endometrial polyps were more frequently found among those treated for > 48 months. Overall, 20.7% of the 164 tamoxifen-treated patients in the study had an endometrial pathology. It can be concluded that there is a slight tendency among those postmenopausal patients who have been treated for > 48 consecutive months to have a higher frequency of endometrial lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|