Entry of influenza A virus into host cells — recent progress and remaining challenges
| Autor: | Milagros Sempere Borau, Silke Stertz |
|---|---|
| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2021 |
| Předmět: |
10028 Institute of Medical Virology
0301 basic medicine Viral Hemagglutinin 030106 microbiology Neuraminidase Virus Attachment Hemagglutinin Glycoproteins Influenza Virus 610 Medicine & health Biology Virus Replication medicine.disease_cause Viral Matrix Proteins 03 medical and health sciences Human health Virology Influenza Human Influenza A virus medicine Viral neuraminidase Humans Viral matrix protein Host Microbial Interactions Host (biology) Virus Uncoating Influenza a Hydrogen-Ion Concentration Virus Internalization 030104 developmental biology Host-Pathogen Interactions 2406 Virology 570 Life sciences biology |
| Zdroj: | Current Opinion in Virology. 48:23-29 |
| ISSN: | 1879-6257 |
| DOI: | 10.1016/j.coviro.2021.03.001 |
| Popis: | Influenza A viruses (IAV) are a major burden for human health and thus the topic of intense research efforts. The entry of IAV into host cells is of particular interest as early infection steps are the ideal target for intervention strategies. Here, we review recent key findings in the field of IAV entry. Specifically, we discuss the identification of novel entry receptors, the emerging role of the viral neuraminidase in entry, as well as recent progress from structural studies on the viral hemagglutinin during the fusion process and the viral matrix protein involved in virus uncoating. We also highlight remaining gaps in our understanding of IAV entry and point out important questions for ongoing research efforts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect