Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy
| Autor: | Mary C Cambou, Christine M Liu, Thalia Mok, Viviana Fajardo-Martinez, Sophia G Paiola, Francisco J Ibarrondo, Tara Kerin, Trevon Fuller, Nicole H Tobin, Gustavo Garcia, Debika Bhattacharya, Grace M Aldrovandi, Vaithilingaraja Arumugaswami, Suan-Sin Foo, Jae U Jung, Zilton Vasconcelos, Patricia Brasil, Michelle Brendolin, Otto O Yang, Rashmi Rao, Karin Nielsen-Saines |
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| Rok vydání: | 2022 |
| Předmět: |
Mothers
Reproductive health and childbirth Medical and Health Sciences Microbiology Antibodies Vaccine Related Pregnancy Clinical Research SARS-CoV-2 in pregnancy Biodefense Infant Mortality Humans Immunology and Allergy Viral Lung Pediatric SARS-CoV-2 Prevention Infant COVID-19 Pneumonia Perinatal Period - Conditions Originating in Perinatal Period Biological Sciences Newborn COVID-19 in pregnancy Immunoglobulin A Emerging Infectious Diseases Good Health and Well Being Infectious Diseases Immunoglobulin M transplacental transfer Immunoglobulin G Female Immunization Biotechnology |
| Zdroj: | The Journal of infectious diseases, vol 227, iss 2 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background There are limited data on how coronavirus disease 2019 (COVID-19) severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies. Methods In a longitudinal cohort of pregnant women with polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike immunoglobulin (Ig)G, IgM, and IgA were measured by enzyme-linked immunosorbent assay. Results Two-hundred fifty-six pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least 1 isotype. Symptomatic disease and vaccination before delivery were associated with higher maternal IgG at labor and delivery. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (odds ratio [OR] = 4.0), mild/moderate disease (OR = 4.8), severe/critical disease (OR = 6.3), and maternal vaccination before delivery (OR = 18.8). No factors were significant in the multivariate analysis at 6 months postpartum. Conclusions Vaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads. |
| Databáze: | OpenAIRE |
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