Iron metabolism in infections: Focus on COVID-19
| Autor: | Giacomo Marchi, Domenico Girelli, Fabiana Busti, Alice Vianello |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Iron
Antimicrobial peptides Hepcidin WMD weighted mean difference SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Article Immune system Immunity Innate Humans Lymphocytes Antigen-presenting cell Pandemics IQR interquartile range COVID-19 coronavirus disease 2019 Ferritin Innate immune system biology MLA machine learning approaches TSAT transferrin saturation COVID-19 Hematology Metabolism TFr1 transferrin receptor 1 Micronutrient Immunity Innate Immunology biology.protein MIS-C multisystem inflammatory syndrome in children (MIS-C) |
| Zdroj: | Seminars in Hematology |
| ISSN: | 1532-8686 0037-1963 |
| Popis: | Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living organisms. During infections, a battle for iron takes place between the human host and the invading pathogens. The liver peptide hepcidin, which is phylogenetically and structurally linked to defensins (antimicrobial peptides of the innate immunity), plays a pivotal role by subtracting iron to pathogens through its sequestration into host cells, mainly macrophages. While this phenomenon is well studied in certain bacterial infections, much less is known regarding viral infections. Iron metabolism also has implications on the functionality of cells of the immune system. Once primed by the contact with antigen presenting cells, lymphocytes need iron to sustain the metabolic burst required for mounting an effective cellular and humoral response. The COVID-19 pandemic has boosted an amount of clinical and translational research over the possible influences of nutrients on SARS-CoV-2 infection, in terms of either susceptibility or clinical course. Here we review the intersections between iron metabolism and COVID-19, belonging to the wider domain of the so-called "nutritional immunity". A better understanding of such connections has potential broad implications, either from a mechanistic standpoint, or for the development of more effective strategies for managing COVID-19 and possible future pandemics. |
| Databáze: | OpenAIRE |
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