Revealing Differential Interaction Forces during Nanopore DNA Sequencing
| Autor: | Xinjia Zhao, Wei Li, Xiaoyu Chen, Yuru Liu, Zhuang Mi, Xinghua Lu, Xinyan Shan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
010304 chemical physics Hydrogen bond Nucleotides Resolution (electron density) Sequence (biology) DNA Sequence Analysis DNA 010402 general chemistry 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films chemistry.chemical_compound Nanopore Nanopores chemistry Drag Chemical physics 0103 physical sciences Materials Chemistry Molecule Nanotechnology Nanopore sequencing Physical and Theoretical Chemistry |
| Zdroj: | The journal of physical chemistry. B. 125(19) |
| ISSN: | 1520-5207 |
| Popis: | The interaction between DNA and the nanopore structure plays an important role in nanopore DNA sequencing. Differential interaction forces between each base type and the nanopore structure are obtained by examining the correlation between translocation dwell time and the sequence. The viscous drag force and the intermolecular interaction are identified with single-nucleotide resolution. Active hydrogen donors and acceptors on the inner wall of the nanopore structure are revealed at various offset coordinates. The differential forces as demonstrated in this study have great potential in probing active hydrogen bond interaction in a single protein molecule with subnanometer spatial resolution. |
| Databáze: | OpenAIRE |
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