A rapid and quantitative mass spectrometry method for determining the concentration of acylcarnitines and aminoacids in amniotic fluid
| Autor: | Michele Boniotto, Laura Braida, Antonio Amoroso, Ariella Luchesi, Sergio Crovella, Bruno Casetta, Umberto de Vonderweid |
|---|---|
| Přispěvatelé: | Braida, L, Crovella, Sergio, Boniotto, M, Luchesi, A, DE VONDERWEID, Umberto, Casetta, B, Amoroso, A., Braida, Laura, Boniotto, Michele, Amoroso, Antonio |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Prenatal Diagnosi
Amniotic fluid Fetal Disease Predictive Value of Test Mass spectrometry Tandem mass spectrometry Sensitivity and Specificity Mass Spectrometry Metabolic Diseases Predictive Value of Tests Pregnancy Carnitine Prenatal Diagnosis Humans Amino Acids Genetics (clinical) Amniotic Fluid Female Fetal Diseases Measurement method Acylcarnitines Aminoacids Chemistry Obstetrics and Gynecology Metabolic Disease Amino Acid Biochemistry Quantitative analysis (chemistry) Human |
| Popis: | We describe a quantitative, rapid, sensitive and reproducible tandem mass spectrometry (MSMS) method for the one-step detection of aminoacid (AAs) and acylcarnitine (ACs) concentrations in amniotic fluid. This technology is quicker and more sensitive than other methods used to date since it is possible to determine very low AA and AC concentrations in samples simultaneously in a single run. The high degree of automation allows a large number of pregnancies to be screened for metabolic defects in a very short time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|