The association of vitamin D levels and insulin resistance
| Autor: | Reza Homayounfar, Amirali Ebrahim Babaei, Jalaledin Mirzay Razzaz, Hadi Raeisi Shahraki, Alireza Ghaemi, Elham Ehrampoush, Hossein arjmand, Saeed Osati |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Inverse Association Waist Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Iran vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine Vitamin D and neurology Humans Insulin Vitamin D 030109 nutrition & dietetics Nutrition and Dietetics business.industry medicine.disease Cross-Sectional Studies Endocrinology Diabetes Mellitus Type 2 Female Insulin Resistance business |
| Zdroj: | Clinical Nutrition ESPEN. 42:325-332 |
| ISSN: | 2405-4577 |
| DOI: | 10.1016/j.clnesp.2021.01.012 |
| Popis: | Vitamin D deficiency and insulin resistance have great prevalence in society. The latest studies indicate an inverse association between Vitamin D levels, insulin resistance, and Type 2 diabetes. The objective of this study was to investigate the effect of vitamin D status on insulin resistance.In a cross-sectional study, 2160 participants were randomly recruited from a nutrition clinic in Tehran, Iran, 1057 (48.9%) were female and 1103 (51.1%) male. Information was gathered by a questionnaire. Following 12-h fasting, fasting plasma glucose (FPG) and insulin levels, as well as 25-hydroxy vitamin D levels were measured. 2-H glucose and insulin levels measured after consumption of 75 g glucose, HOMA2-IR, and HOMA-β indices were then calculated.The average serum Vitamin D was 22.3 + 8.9 nmol/L and the prevalence of Vitamin D deficiency was 100%. There was an inverse relationship between Vitamin D levels and age, BMI, waist circumference, and all metabolic parameters (p 0.001 in all) and a direct association with levels of exercise. Two logistic regression models were used to adjust for confounding variables; firstly, for age, gender, and smoking and secondly, additionally for BMI and energy intake. Both models showed a significant inverse relationship between Vitamin D levels and FPG and insulin levels, 2-h glucose and insulin levels, and HOMA2-IR. The optimum cut point for vitamin D was calculated at about 25 nmol/L for preventing insulin resistance.This study illustrated that there is a statistically significant inverse relationship between Vitamin D levels and insulin resistance. |
| Databáze: | OpenAIRE |
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