Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Autor:	Michal Mego, Andrej Jurik, Barbora Vlková, Jozef Sufliarsky, Peter Celec, Jozef Mardiak, Michaela Kubickova, Denisa Manasova, Tomas Minarik, Katarina Kalavska
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Oncology medicine.medical_specialty Bevacizumab medicine.medical_treatment lcsh:Gynecology and obstetrics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Prognostic marker Extracellular DNA Ovarian cancer Ovarian carcinoma Internal medicine Humans Medicine Prospective Studies lcsh:RG1-991 Ovarian Neoplasms Chemotherapy business.industry Research Obstetrics and Gynecology Cancer DNA Prognosis medicine.disease Debulking Carboplatin Plasma DNA 030104 developmental biology Real-time polymerase chain reaction chemistry 030220 oncology & carcinogenesis Female business medicine.drug
Zdroj:	Journal of Ovarian Research, Vol 11, Iss 1, Pp 1-7 (2018) Journal of Ovarian Research
ISSN:	1757-2215
DOI:	10.1186/s13048-018-0459-z
Popis:	Background Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer including ovarian carcinoma. Whether total circulating DNA, which can be assessed much easier without knowing the tumor-specific mutations, has similar informative value is currently unknown. The aim of this study was to evaluate the prognostic value of extracellular DNA in advanced ovarian cancer. Methods This prospective study included 67 patients (pts) with ovarian cancer treated with 1st line paclitaxel and carboplatin (25 pts) and paclitaxel, carboplatin and bevacizumab (42 pts). Thirty-five patients had optimal surgical debulking before chemotherapy. Extracellular DNA was quantified using real time PCR before administration of chemotherapy (67 pts) and after 6 cycles of chemotherapy (44 pts). Results Total extracellular DNA (ecDNA), as well as extracellular DNA of nuclear (nDNA) and mitochondrial origin (mtDNA) significantly (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbcf9512fc0edfd0d387b398bc7607a http://link.springer.com/article/10.1186/s13048-018-0459-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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