Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain

Autor:	Habip Yılmaz, Aslıhan Şengelen, Serdar Demirgan, Hüsniye Esra Paşaoğlu, Melike Çağatay, İbrahim Emre Erman, Mehmet Bay, Hasan Cem Güneyli, Evren Önay-Uçar
Rok vydání:	2022
Předmět:	Health Toxicology and Mutagenesis Toxicology
Zdroj:	Toxicology Mechanisms and Methods. 33:279-292
ISSN:	1537-6524 1537-6516
DOI:	10.1080/15376516.2022.2127389
Popis:	Damage to hippocampus, cerebellum, and cortex associated with cognitive functions due to anesthetic-induced toxicity early in life may cause cognitive decline later. Aquaporin 4 (AQP4), a key protein in waste clearance pathway of brain, is involved in synaptic plasticity and neurocognition. We investigated the effects of single and repeated isoflurane (Iso) anesthesia on AQP4 levels and brain damage. Postnatal-day (P)7 Wistar albino rats were randomly assigned to Iso or Control (C) groups. For single-exposure, pups were exposed to 1.5% Iso in 30% oxygenated-air for 3-h at P7 (Iso
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbc2336de80d6d5391d457034794f1d https://doi.org/10.1080/15376516.2022.2127389 Zobrazit plný text záznamu