Kupffer Cell Hyaline Globules in Children With Autoimmune Hepatitis
| Autor: | Ramy Mohamed Ghazy, Menan E. Salem, Ahmed S Elharoun, Nermin M. Adawy, Mervat M Sultan, Tahany A. Salim, Nermine A. Ehsan, Mohammed A. Khedr |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry Kupffer cell Retrospective cohort study Disease Autoimmune hepatitis medicine.disease Stain Gastroenterology digestive system diseases Virus Serology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure immune system diseases 030220 oncology & carcinogenesis Internal medicine medicine Original Article 030211 gastroenterology & hepatology business Hyaline |
| Zdroj: | J Clin Exp Hepatol |
| ISSN: | 0973-6883 |
| DOI: | 10.1016/j.jceh.2021.04.013 |
| Popis: | BACKGROUND: Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCLDs). MATERIALS AND METHODS: This retrospective study recruited 124 children; 58 with AIH, 50 with chronic hepatitis C virus (HCV) infection, and 16 with Wilson’s disease (WD). Two pathologists retrieved paraffin blocks of liver biopsies and prepared new cut sections for Periodic acid–Schiff–Diastase (PAS-D) stain. They independently examined liver biopsies before starting treatment. Two pediatricians reviewed medical records for demographic, clinical, laboratory, and serological findings. RESULTS: Females represented 48.6% of the studied children with a median age of 5.8 (4.9) years. Pathologists identified KCHGs in 67.24%, 12.5%, and 6.0% of AIH, WD, and HCV affected children respectively, P |
| Databáze: | OpenAIRE |
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