Comparison between plasma neopterin and the urine neopterin:creatinine ratio as inflammatory biomarkers
| Autor: | Bianca Lee Thomas, Margaretha Viljoen, Priyesh Bipath |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Databases Factual 030231 tropical medicine Urine Systemic inflammation Gastroenterology Neopterin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases Internal medicine medicine Humans Body fluid Inflammation Creatinine business.industry biomarkers General Medicine Articles Prognosis Inflammatory biomarkers Neopterin/Creatinine chemistry Africa Biomarker (medicine) Neopterin inflammation biomarkers renal creatinine renal medicine.symptom business |
| Zdroj: | African Health Sciences African Health Sciences; Vol 19, No 3 (2019); 2407-2413 |
| ISSN: | 1729-0503 1680-6905 |
| Popis: | Background: Neopterin, a product of cell-mediated immunity, is a non-specific biomarker of inflammation. Plasma/serum is generally the body fluid of choice for neopterin assessment, but urine is often used as it does away with venepuncture. Analysis of urine neopterin is based on collection of a single urine sample and expressed as μmol neopterin/mol creatinine.Objectives: To examine published correlations between plasma neopterin levels and urine neopterin:creatinine ratios and to determine whether they are in diagnostic agreement. Methods: Literature search was performed by databases and by hand. Databases included Academic Search Complete; Africa-Wide Information; AHFS Consumer Medication Information; eBook Collection (EBSCOhost); Family & Society Studies Worldwide; MasterFILE Premier; MEDLINE; TOC Premier.Results: Positive correlations of varying statistical significance generally exist between plasma neopterin and urine neopterin:creatinine ratios. With a decline in renal clearance, plasma neopterin over-estimates inflammatory activity. With immune-complex renal disease, urine neopterin:creatinine ratios over-estimate systemic inflammation. The two biomarkers can differ in diagnostic validity.Conclusion: Correlations between plasma neopterin and urine neopterin:creatinine ratios suggest both as suitable biomarkers. However, since correlations reflect equality of means and not individual values, significant correlations, do not necessarily imply diagnostic agreement. Therefore, plasma and urine cannot summarily be assumed interchangeable for diagnostic/prognostic purposes.Keywords: Neopterin, inflammation, biomarkers, renal, creatinine. |
| Databáze: | OpenAIRE |
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