Effect of intermittent phototherapy on bilirubin dynamics in Gunn rats
| Autor: | Thomas A. Blumenfeld, Cheskin Hs, William T. Speck, Koenigsberger Mr, Thomas P. Vogl |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Continuous therapy
Male medicine.medical_specialty Time Factors Bilirubin Statistics as Topic chemistry.chemical_compound Sex Factors Dark therapy Light Cycle Intermittent phototherapy medicine Animals business.industry Jaundice Phototherapy Surgery Rats Dose–response relationship Kinetics chemistry Anesthesia Concomitant Pediatrics Perinatology and Child Health Female medicine.symptom business |
| Zdroj: | Pediatric research. 11(10 Pt 1) |
| ISSN: | 0031-3998 |
| Popis: | Summary: To determine whether continuous phototherapy is necessary to control neonatal jaundice, groups of jaundiced (Gunn) rats were exposed to four blue light regimens: continuous light, 30 min light/30 min dark, 6 min light/6 min dark, and 6 min light/18 min dark. An exponential decrease in serum bilirubin concentration (SBC) was found with all regimens. A logarithmic dose response curve was obtained with a 50% light dose exhibiting 75% efficacy, and a 25% light dose exhibiting 59% efficacy compared to continuous phototherapy. The time constants of the decrease in serum bilirubin concentration also varied logarithmically with doses with continuous therapy having a time constant of 1.4 days, and 6 min light/18 min dark therapy having a time constant of 3 days. Speculation: In view of the concern which has been expressed over the potential long term side effects of phototherapy, the present study suggests that intermittent phototherapy, with a light cycle of approximately 30–60 min duration, and a concomitant dosage decrease of 50–75% may effectively control neonatal hyperbilirubinemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|