Cordycepin Inhibition of 3-Methylcholanthrene-Induced Transformation In Vitro
| Autor: | Robert J. Huebner, Robert L. Peters, Paul J. Price, William A. Suk, Carolyn E. Martin, Teresa M. Bellew |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Deoxyadenosines
Cordycepin Idoxuridine RNA-Directed DNA Polymerase Endogeny Molecular biology General Biochemistry Genetics and Molecular Biology In vitro Cell Line chemistry.chemical_compound Transformation (genetics) Cell Transformation Neoplastic Retroviridae Deoxyadenosine chemistry Cell culture Methylcholanthrene medicine medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 150:650-653 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-150-39098 |
| Popis: | Cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type "C" RNA virus by 5-iodo-2'-deoxyuridine in a line of Fisher rat embryo cells (H43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene. |
| Databáze: | OpenAIRE |
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