The tumour microenvironment and immune milieu of cholangiocarcinoma
| Autor: | Joachim C. Mertens, Alexander Siebenhüner, Antonio Solinas, Thorsten Cramer, Veronika Lukacs-Kornek, Hanna Sänger, Luca Fabris, Niklas K. Björkström, Ana Lleo, Maria J. Perugorria, Mario Strazzabosco, Anja Moncsek |
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| Přispěvatelé: | Fabris, L, Perugorria, M, Mertens, J, Bjorkstrom, N, Cramer, T, Lleo, A, Solinas, A, Sanger, H, Lukacs-Kornek, V, Moncsek, A, Siebenhuner, A, Strazzabosco, M |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
cancer associated fibroblasts
medicine.medical_treatment NEUTROPHIL-TO-LYMPHOCYTE bile ducts Adaptive Immunity Cholangiocarcinoma liver neoplasia angiogenesis NATURAL-KILLER-CELLS 0302 clinical medicine PROGNOSTIC-SIGNIFICANCE Tumor Microenvironment cancer associated fibroblasts extracellular matrix immune cells immunotherapy tumor associated macrophages tumor reactive stroma Adaptive Immunity Animals Bile Duct Neoplasms Cholangiocarcinoma Disease Models Animal Endothelial Cells Fibroblasts Humans Immunity Innate Tumor Microenvironment education.field_of_study tumor associated macrophages Acquired immune system EPITHELIAL-MESENCHYMAL TRANSITION CANCER-ASSOCIATED FIBROBLASTS 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology tumor reactive stroma immunotherapy Stromal cell INFILTRATING LYMPHOCYTES extracellular matrix Population HEPATIC STELLATE CELLS Biology liver neoplasia cholangiocarcinoma cancer associated fibroblast ECM bile ducts angiogenesis DENDRITIC CELLS 03 medical and health sciences Immune system immune cells Pancreatic cancer medicine CARCINOMA-ASSOCIATED FIBROBLASTS Animals Humans INTRAHEPATIC CHOLANGIOCARCINOMA education Tumor microenvironment ECM Hepatology Endothelial Cells Immunotherapy Fibroblasts medicine.disease Immunity Innate Disease Models Animal cancer associated fibroblast Bile Duct Neoplasms Cancer research Cancer-Associated Fibroblasts |
| Popis: | Tumour microenvironment is a complex, multicellular functional compartment that, particularly when assembled as an abundant desmoplastic reaction, may profoundly affect the proliferative and invasive abilities of epithelial cancer cells. Tumour microenvironment comprises not only stromal cells, mainly cancer-associated fibroblasts, but also immune cells of both the innate and adaptive system (tumour-associated macrophages, neutrophils, natural killer cells, and T and B lymphocytes), and endothelial cells. This results in an intricate web of mutual communications regulated by an extensively remodelled extracellular matrix, where the tumour cells are centrally engaged. In this regard, cholangiocarcinoma, in particular the intrahepatic variant, has become the focus of mounting interest in the last years, largely because of the lack of effective therapies despite its rising incidence and high mortality rates worldwide. On the other hand, recent studies in pancreatic cancer, which similarly to cholangiocarcinoma, is highly desmoplastic, have argued against a tumour-promoting function of the tumour microenvironment. In this review, we will discuss recent developments concerning the role of each cellular population and their multifaceted interplay with the malignant biliary epithelial counterpart. We ultimately hope to provide the working knowledge on how their manipulation may lead to a therapeutic gain in cholangiocarcinoma. |
| Databáze: | OpenAIRE |
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