Early neurodevelopmental outcomes of infants with intestinal failure
| Autor: | Christina Kosar, Karolina Maria Burghardt, Stephanie So, Catherine Patterson, Anna Gold, Alaine Rogers, Nicole de Silva, Yaron Avitzur, Paul W. Wales |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neonatal intensive care unit Birth weight Gross motor skill Intestinal Atresia Cerebral palsy 03 medical and health sciences 0302 clinical medicine Child Development Interquartile range Enterocolitis Necrotizing 030225 pediatrics medicine Humans 030212 general & internal medicine Gastroschisis business.industry Infant Newborn Obstetrics and Gynecology Gestational age medicine.disease Low birth weight Neurodevelopmental Disorders Pediatrics Perinatology and Child Health Necrotizing enterocolitis Female medicine.symptom business Digestive System Abnormalities Infant Premature Intestinal Volvulus |
| Zdroj: | Early human development. 101 |
| ISSN: | 1872-6232 |
| Popis: | Background The survival rate of infants and children with intestinal failure is increasing, necessitating a greater focus on their developmental trajectory. Aims To evaluate neurodevelopmental outcomes in children with intestinal failure at 0–15 months corrected age. Study design Analysis of clinical, demographic and developmental assessment results of 33 children followed in an intestinal rehabilitation program between 2011 and 2014. Outcome measures included: Prechtl's Assessment of General Movements, Movement Assessment of Infants, Alberta Infant Motor Scale and Mullen Scales of Early Learning. Clinical factors were correlated with poorer developmental outcomes at 12–15 months corrected age. Results Thirty-three infants (17 males), median gestational age 34 weeks (interquartile range 29.5–36.0) with birth weight 1.98 kg (interquartile range 1.17–2.50). Twenty-nine (88%) infants had abnormal General Movements. More than half had suspect or abnormal scores on the Alberta Infant Motor Scale and medium to high-risk scores for future neuromotor delay on the Movement Assessment of Infants. Delays were seen across all Mullen subscales, most notably in gross motor skills. Factors significantly associated with poorer outcomes at 12–15 months included: prematurity, low birth weight, central nervous system co-morbidity, longer neonatal intensive care admission, necrotizing enterocolitis diagnosis, number of operations and conjugated hyperbilirubinemia. Conclusion Multiple risk factors contribute to early developmental delay in children with intestinal failure, highlighting the importance of close developmental follow-up. |
| Databáze: | OpenAIRE |
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