Glycopyrrolate does not ameliorate hypothermia associated bradycardia in healthy individuals: A randomized crossover trial
| Autor: | Alexandra Weissman, Melissa J. Repine, David Richard Hopkins, Jon C. Rittenberger, Ankur A. Doshi, Kelly N. Sawyer, Clifton W. Callaway, Cameron Dezfulian, Katharyn L Flickinger, Jonathan Elmer, Francis X. Guyette |
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| Rok vydání: | 2020 |
| Předmět: |
Bradycardia
Adult Male Hypothermia 030204 cardiovascular system & hematology Emergency Nursing Article 03 medical and health sciences Young Adult 0302 clinical medicine Heart rate medicine Humans Dexmedetomidine Glycopyrrolate Cross-Over Studies business.industry 030208 emergency & critical care medicine Anesthesia Austria Emergency Medicine Shivering Premedication Female medicine.symptom Bolus (digestion) Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Resuscitation |
| ISSN: | 1873-1570 |
| Popis: | BACKGROUND: Hypothermia improves outcomes following ischemia-reperfusion injury. Shivering is common and can be mediated by agents such as dexmedetomidine. The combination of dexmedetomidine and hypothermia results in bradycardia. We hypothesized that glycopyrrolate would prevent bradycardia during dexmedetomidine-mediated hypothermia. METHODS: We randomly assigned eight healthy subjects to premedication with a single 0.4mg glycopyrrolate intravenous (IV) bolus, titrated glycopyrrolate (0.01mg IV every 3 minutes as needed for heart rate 0.05). Mean arterial blood pressure was higher in the glycopyrrolate bolus condition (p |
| Databáze: | OpenAIRE |
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