HLA‐DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population
| Autor: | C. Azqueta, E. Matas, T. Arbizu, S. Martínez-Yélamos, J. M. Pujal, L. Gubieras, L. Bau, M. Torrabadella, L. Romero-Pinel |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male musculoskeletal diseases Pathology medicine.medical_specialty Multiple Sclerosis Genotype Population Polymerase Chain Reaction Polymorphism Single Nucleotide immune system diseases Internal medicine Genetic predisposition Humans Medicine Genetic Predisposition to Disease skin and connective tissue diseases education HLA-DRB1 Alleles Univariate analysis education.field_of_study business.industry Multiple sclerosis Haplotype HLA-DR Antigens Odds ratio medicine.disease Neurology Spain Disease Progression Female Neurology (clinical) business HLA-DRB1 Chains |
| Zdroj: | European Journal of Neurology. 18:337-342 |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/j.1468-1331.2010.03148.x |
| Popis: | Background and objective: The association of HLA-DRB1*15 with susceptibility to multiple sclerosis (MS) has been consistently reported although its effect on the clinical phenotype is still controversial. The objectives of this study are to investigate the influence of the HLA-DRB1 alleles on the genetic susceptibility to MS and to study their impact on disability progression in a Spanish population. Methods: HLA-DRB1 typing was performed by PCR-SSP in 380 patients with sporadic MS and 1088 unrelated healthy controls. Allelic frequencies were compared between groups. We studied the correlation between the different alleles and the progression of MS. Results: The HLA-DRB1*15 allele in patients with MS had a statistically significant higher frequency when compared with controls (18.9% in patients vs. 10.1% in controls, Odds ratio (OR) = 2.07, 95% CI = 1.64–2.60, P |
| Databáze: | OpenAIRE |
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