Handheld Diffuse Reflectance Spectral Imaging (DRSi) for in-vivo characterization of skin
| Autor: | Youmin Wang, Jason S. Reichenberg, John X. J. Zhang, Manu Sharma, Sheldon Bish, Nicholas Triesault, James W. Tunnell |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Materials science Diffuse reflectance infrared fourier transform business.industry Scattering Hyperspectral imaging Image processing Atomic and Molecular Physics and Optics Diffuse optical imaging Clinical Instrumentation Spectral imaging Optics Optical transfer function medicine Diffuse reflection sense organs business Biotechnology |
| Zdroj: | Biomedical optics express. 5(2) |
| ISSN: | 2156-7085 |
| Popis: | Diffuse reflectance spectroscopy provides a noninvasive means to measure optical and physiological properties of tissues. To expand on these measurements, we have developed a handheld diffuse reflectance spectral imaging (DRSi) system capable of acquiring wide field hyperspectral images of tissue. The image acquisition time was approximately 50 seconds for a 50x50 pixel image. A transport model was used to fit each spectra for reduced scattering coefficient, hemoglobin concentration and melanin concentration resulting in optical property maps. The system was validated across biologically relevant levels of reduced scattering (5.14% error) and absorption (8.34% error) using tissue simulating phantoms. DRSi optical property maps of a pigmented skin lesion were acquired in vivo. These trends in optical properties were consistent with previous observations using point probe devices. |
| Databáze: | OpenAIRE |
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