The accuracy of transrectal ultrasonography supplemented with computer-aided ultrasonography for detecting small prostate cancers
| Autor: | Karien Treurnicht, Cristina Soviany, Rina Nir, S Govindaraju, Michael Jarmulowicz, Mark Emberton, Philippe Autier, Dror Nir, Johan G. Braeckman, Dirk Michielsen, Harry Bleiberg |
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| Přispěvatelé: | Gyneacology-Urology, Surgery Specializations |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Medical diagnostic Pathology diagnosis Urology medicine.medical_treatment Risk Assessment Sensitivity and Specificity Small prostate Prostate Image Interpretation Computer-Assisted Humans Medicine Ultrasonography Prostate cancer HistoScanning medicine.diagnostic_test business.industry Prostatectomy Prostatic Neoplasms Cancer medicine.disease medicine.anatomical_structure Lower threshold Transrectal ultrasonography Radiology business |
| Zdroj: | BJU International. 102:1560-1565 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2008.07878.x |
| Popis: | OBJECTIVE To determine the extent to which computer-aided ultrasonography of the prostate (HistoScanningTM, Advanced Medical Diagnostics, Waterloo, Belgium) can identify tumour foci that correspond to a volume of ≥0.50 mL. PATIENTS AND METHODS Between September 2004 and February 2006, 29 men were HistoScanned before scheduled radical prostatectomy. The three-dimensional raw (grey-scaled) data required for HistoScanning analysis were acquired by transrectal ultrasonography, and analysed using organ-specific tissue-characterization algorithms which form the core of the HistoScanning technology. The HistoScanning analysis results were compared with the histology of the whole-mounted prostate, step-sectioned sagittally at 5-mm intervals, and each slide analysed by 5 × 5 mm grid analysis. RESULTS Of 29 patients, 13 had histology unknown to those evaluating the HistoScanning data. With 0.50 mL as the lower threshold for delineating and visualizing cancer volume, HistoScanning correctly predicted the presence of all 12 lesions that were subsequently confirmed to occupy ≥0.50 mL. In addition three lesions were predicted as being present and of ≥0.50 mL. These three lesions were subsequently confirmed to be present but were ≤0.50 mL on histopathological review. Thus, using the clinically accepted volume threshold of 0.50 mL, the sensitivity, specificity, positive and negative predictive value of HistoScanning were 12/12, 13/16 (82%), 12/15 (80%) and 12/12, respectively, for the cancer foci analysed. CONCLUSIONS In this preliminary study, HistoScanning accurately detected cancer foci of ≥0.50 mL; these encouraging results will need to be verified in a larger group of patients. |
| Databáze: | OpenAIRE |
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