Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease
| Autor: | Tetsuya Iida, Chiao-Ching Hsu, Ryu Okumura, Daisuke Motooka, Reo Sasaki, Kiyoshi Takeda, Shota Nakamura |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Colon Immunology Motility Inflammation Diet High-Fat GPI-Linked Proteins Inflammatory bowel disease Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Immunology and Allergy Intestinal Mucosa Colitis biology business.industry Dextran Sulfate Mucous membrane Inflammatory Bowel Diseases General Medicine medicine.disease biology.organism_classification Gastrointestinal Microbiome Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure Dysbiosis Female 030211 gastroenterology & hepatology medicine.symptom business Bacteria |
| Zdroj: | International Immunology. 33:359-372 |
| ISSN: | 1460-2377 |
| DOI: | 10.1093/intimm/dxab012 |
| Popis: | Dysfunction of the intestinal mucosal barrier causes inflammatory bowel diseases (IBDs). Indeed, mucosal barrier impairment in the gut of IBD patients results from decreased expression of barrier molecules. Ly6/Plaur domain containing 8 (Lypd8) segregates microbiota from the colonic epithelial layer. In this study, we found that Lypd8−/− mice, in which flagellated bacteria invaded the mucosal surface of the colon, developed spontaneous colitis when dysbiosis was induced by a high-fat diet (HFD). On the basis of this finding, we assessed whether the application of human LYPD8 (hLYPD8) protein exhibiting the glycan-dependent inhibition of bacterial motility is effective in a colitis model. Oral and anal treatments with hLYPD8 protein ameliorate dextran sulfate sodium-induced colitis and HFD-induced colitis in Lypd8−/− mice. These results indicate a therapeutic potential of hLYPD8 protein supplementation for IBD. |
| Databáze: | OpenAIRE |
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