Genetic Regulation of Biomarkers as Stress Proxies in Dairy Cows
| Autor: | Erminio Trevisi, Sandy Sgorlon, Katia Cappelli, Bruno Stefanon, Matilde Maria Passamonti, Mariasilvia D'Andrea, Valentino Palombo, John L. Williams, Stefano Capomaccio, Andrea Minuti, Paolo Ajmone-Marsan, Marco Milanesi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 Physiological Quantitative Trait Loci Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Article Biomarkers Candidate loci Cattle Genetics Stress Animals Aryldialkylphosphatase Ceruloplasmin Genomics gamma-Glutamyltransferase Gene Expression Regulation Genome-Wide Association Study Stress Physiological 03 medical and health sciences stress Immune system genetics candidate loci Polymorphism Gene Genetics (clinical) Genetic association Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO 0402 animal and dairy science Paraoxonase Settore AGR/19 - ZOOTECNICA SPECIALE Single Nucleotide 04 agricultural and veterinary sciences 040201 dairy & animal science Breed lcsh:Genetics 030104 developmental biology biology.protein Liver function |
| Zdroj: | Genes Volume 12 Issue 4 Genes, Vol 12, Iss 534, p 534 (2021) |
| ISSN: | 2073-4425 |
| Popis: | Stress in livestock reduces productivity and is a welfare concern. At a physiological level, stress is associated with the activation of inflammatory responses and increased levels of harmful reactive oxygen species. Biomarkers that are indicative of stress could facilitate the identification of more stress-resilient animals. We examined twenty-one metabolic, immune response, and liver function biomarkers that have been associated with stress in 416 Italian Simmental and 436 Italian Holstein cows which were genotyped for 150K SNPs. Single-SNP and haplotype-based genome-wide association studies were carried out to assess whether the variation in the levels in these biomarkers is under genetic control and to identify the genomic loci involved. Significant associations were found for the plasma levels of ceruloplasmin (Bos taurus chromosome 1—BTA1), paraoxonase (BTA4) and γ-glutamyl transferase (BTA17) in the individual breed analysis that coincided with the position of the genes coding for these proteins, suggesting that their expression is under cis-regulation. A meta-analysis of both breeds identified additional significant associations with paraoxonase on BTA 16 and 26. Finding genetic associations with variations in the levels of these biomarkers suggests that the selection for high or low levels of expression could be achieved rapidly. Whether the level of expression of the biomarkers correlates with the response to stressful situations has yet to be determined. |
| Databáze: | OpenAIRE |
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