Regulation of Adaptive Tumor Immunity by Non-Coding RNAs

Autor: Laura Gámez-Reche, Eleftheria Papaioannou, Alicia Gonzalez-Martin, Ana M Prieto-Muñoz, María Del Pilar González-Molina
Přispěvatelé: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Asociación Española Contra el Cáncer, Comunidad de Madrid, Universidad Autónoma de Madrid
Rok vydání: 2021
Předmět:
Zdroj: Cancers
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 13, Iss 5651, p 5651 (2021)
ISSN: 2072-6694
2018-1000
Popis: © 2021 by the authors.
Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy.
Our laboratory is funded by grants RTI2018-100008-A-I00 by MCIN/AEI/10.13039/ 501100011033/ and FEDER “Una manera de hacer Europa”, LAB-AECC 2020 from Spanish Association Against Cancer, SI1-PJI-2019-00241 from Community of Madrid, and merit award RyC-21155 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro” to A.G.-M., E.P. is supported by the FJC2019-040779-I fellowship funded by MCIN/AEI/10.13039/501100011033, L.G.-R. by the PRE2019-087940 fellowship funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”, and M.d.P.G.-M. by a FPI fellowship from Universidad Autónoma de Madrid.
Databáze: OpenAIRE
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