Cardiorespiratory fitness and right ventricular mechanics in uncomplicated diabetic patients: Is there any relationship?

Autor: Jelena Suzic-Lazic, Vera Celic, Cesare Cuspidi, Marijana Tadic, Guido Grassi, Antonio Esposito, Vladan Vukomanovic, Dusan Skokic
Přispěvatelé: Vukomanovic, V., Suzic-Lazic, J., Celic, V., Cuspidi, C., Skokic, D., Esposito, A., Grassi, G., Tadic, M., Vukomanovic, V, Suzic-Lazic, J, Celic, V, Cuspidi, C, Skokic, D, Esposito, A, Grassi, G, Tadic, M
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Ventricular Dysfunction
Right
Oxygen pulse
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Diabete
03 medical and health sciences
0302 clinical medicine
Endocrinology
Oxygen Consumption
Heart Rate
Internal medicine
Diabetes mellitus
Heart rate
Internal Medicine
Medicine
Humans
Interventricular septum
business.industry
Diabetes
Case-control study
Cardiorespiratory fitness
General Medicine
Middle Aged
medicine.disease
Biomechanical Phenomena
Oxygen uptake
medicine.anatomical_structure
Right ventricular strain
Cross-Sectional Studies
Cardiorespiratory Fitness
Diabetes Mellitus
Type 2
Case-Control Studies
Breathing
Cardiology
Exercise Test
Ventricular Function
Right
Female
business
Zdroj: Acta diabetologica. 57(4)
ISSN: 1432-5233
Popis: Aims: This study investigated the association between cardiorespiratory fitness and right ventricular (RV) strain in uncomplicated diabetic patients. Methods: This cross-sectional study involved 70 controls and 61 uncomplicated patients with type 2 diabetes, who underwent laboratory analysis, comprehensive echocardiographic study and cardiopulmonary exercise testing. Results: RV endocardial and mid-myocardial longitudinal strains were significantly reduced in diabetic subjects (− 27.5 ± 4.2% vs. − 25.3 ± 4.3%, p = 0.004 for endocardial strain; − 25.6 ± 3.5% vs. − 24.1 ± 3.2%, p = 0.012 for mid-myocardial strain). The same was revealed for endocardial and mid-myocardial of RV free wall. There was no difference in RV epicardial strain. VO2 was significantly lower in the diabetic group (27.8 ± 4.5ml/kg/min vs. 21.5 ± 4.2ml/kg/min, p < 0.001), whereas ventilation/carbon dioxide slope was significantly higher in diabetic subjects (25.4 ± 2.9 vs. 28.6 ± 3.3). Heart rate recovery was significantly lower in diabetic patients. HbA1c and global RV endocardial longitudinal strain were independently associated with peak VO2 and oxygen pulse in the whole study population. Conclusion: Diabetes impacts RV mechanics, but endocardial and mid-myocardial layers are more affected than epicardial layer. RV endocardial strain and HbA1c were independently associated with cardiorespiratory fitness in the whole study population. Our findings show that impairment in RV strain and cardiorespiratory fitness may be useful indicators in early type 2 diabetes, prior to the development of further complications.
Databáze: OpenAIRE
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