Effects of a dimeric vs a monomeric nonionic contrast medium on renal function in patients with mild to moderate renal insufficiency: a double-blind, randomized clinical trial
| Autor: | M Assante, R. Antonione, M. A. Cova, Fulvio Stacul, T. Haider, S Petz, Ludovico Dalla Palma, Faccini L, Michele Carraro, F Malalan, B. H. Grynne |
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| Přispěvatelé: | Carraro, Michele, Malalan, F, Antonione, R, Stacul, F, Cova, MARIA ASSUNTA, Petz, S, Assante, M, Grynne, B, Haider, T, DALLA PALMA, L, Faccini, L. |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Iohexol Urinary system Urology Contrast Media Renal function CD13 Antigens Kidney Nephropathy Nephrotoxicity chemistry.chemical_compound Double-Blind Method Triiodobenzoic Acids Acetylglucosaminidase Alpha-Globulins medicine Albuminuria Humans Radiology Nuclear Medicine and imaging Renal Insufficiency Infusions Intravenous Aged Retrospective Studies Aged 80 and over Creatinine business.industry Iopromide Urography General Medicine Middle Aged medicine.disease Iodixanol Contrast medium chemistry Female Radiology Safety business Follow-Up Studies medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s003300050356 |
| Popis: | The efficacy and safety of nonionic dimeric contrast media in subjects with impaired renal function is largely unknown. The present study was aimed at determining the risk of tubular nephrotoxicity in patients with mild to moderate renal insufficiency who underwent intravenous urography (IVU) with the nonionic dimeric contrast agent iodixanol (Visipaque, Nycomed Imaging, Oslo, Norway). In a double-blind protocol 64 patients (55 males; mean age 68.3 years) with serum creatinine between 135 and 265 micromol/l who were to undergo IVU were randomized to receive iodixanol (a nonionic dimer) or iopromide (a nonionic monomer), 600 mg I/kg b. w. Renal function was evaluated before and 1 h, 6 h, 24 h, 48 h and 7 days after IVU with analysis of serum creatinine, urinary enzymes alanylaminopeptidase and N-acetyl-beta-glucosaminidase, and urinary microproteins alpha-1-microglobulin and albumin. Renal function remained stable in both contrast medium groups during the follow-up period. No statistically significant differences were observed between the monomer and the dimer in terms of urinary enzyme and microprotein excretion or serum creatinine. Transient radiocontrast-induced nephropathy developed in 1 patient who had received iodixanol. The administration of the nonionic dimeric contrast medium iodixanol, or of the nonionic monomer iopromide, entailed a low nephrotoxic potential in patients with mild to moderate renal insufficiency undergoing excretory urography. |
| Databáze: | OpenAIRE |
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