The caudate nucleus in obsessive–compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study
| Autor: | Elsebet Steno Hansen, T. G. Bolwig, Ian Law, Steen G. Hasselbalch |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Oncology Obsessive-Compulsive Disorder medicine.medical_specialty Neural substrate Thalamus Caudate nucleus Statistical parametric mapping behavioral disciplines and activities Yale–Brown Obsessive Compulsive Scale Neuroimaging Fluorodeoxyglucose F18 Internal medicine mental disorders Basal ganglia medicine Humans Pharmacology (medical) Cerebral Cortex Psychiatric Status Rating Scales Pharmacology medicine.diagnostic_test Middle Aged Paroxetine Psychiatry and Mental health Glucose Female Caudate Nucleus Radiopharmaceuticals Psychology Neuroscience Selective Serotonin Reuptake Inhibitors Tomography Emission-Computed medicine.drug |
| Zdroj: | The International Journal of Neuropsychopharmacology. 5 |
| ISSN: | 1469-5111 1461-1457 |
| Popis: | Several neuroimaging studies of patients with OCD have pointed to basal ganglia and the frontal cortical regions being relevant for an understanding of the pathophysiology and therapy of OCD. In a search for the neural substrate underlying the therapeutic action of paroxetine in the therapy of OCD we measured regional glucose metabolism in a PET study of 20 OCD patients before and after at least 3 months of treatment. We used 18-fluoro-deoxyglucose PET-scanning to measure regional cerebral glucose metabolic rate (rCMRglc) in 20 non-depressed patients fulfilling DSM-IV criteria for OCD. Patients were studied before and after 12-20 wk of treatment with the serotonin re-uptake inhibitor paroxetine. Clinical assessment rating with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was performed before the first and after the second study. The PET data was analysed regionally using statistical parametric mapping (SPM-96). A clinical improvement was indicated by a mean decrease of 55% in the Y-BOCS score. There was no difference in global cerebral metabolism before and after treatment whereas a post-treatment reduction in normalized rCMRglc was found in the right caudate nucleus. This finding also showed a significant positive correlation with symptom severity. Our results support hypotheses regarding a malfunction of the cortico-striato-thalamic system in the pathophysiology of OCD and particularly point to the caudate nucleus playing an important role for the therapeutic action of paroxetine in the treatment of OCD. |
| Databáze: | OpenAIRE |
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