Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects
| Autor: | Dircilei Nascimento de Sousa, Wagner R. Duarte, Vania Maria Ferreira, Washington Macedo de Santana |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Calcium Phosphates
medicine.medical_specialty Simvastatin RD1-811 Ossos - crescimento H&E stain Bone Matrix 03 medical and health sciences 0302 clinical medicine Osteogenesis Internal medicine medicine Animals Bone formation Rats Wistar Ratos Wound Healing Chemistry Cálcio BoneCeramic Anticholesteremic Agents Skull Rats 030206 dentistry Anatomy Biphasic calcium phosphate Disease Models Animal Endocrinology Trephine Collagen sponge 030220 oncology & carcinogenesis Surgery Female Collagen Hydroxyapatites Wound healing medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Vol 31, Iss 5, Pp 300-307 (2016) Acta Cirurgica Brasileira, Volume: 31, Issue: 5, Pages: 300-307, Published: MAY 2016 Acta Cirúrgica Brasileira v.31 n.5 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| ISSN: | 1678-2674 |
| Popis: | PURPOSE: To investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic(r)) or collagen sponge on bone formation in critical-sized bone defects. METHODS: Thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 - control, no treatment; group 2 (BoneCeramic(r)); group 3 (BoneCeramic(r) + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. RESULTS: The greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic(r) + 0.1mg simvastatin) followed by group 2 (BoneCeramic(r)), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. CONCLUSION: Simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects. |
| Databáze: | OpenAIRE |
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