The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention

Autor: Brinda Rana, Shirley Flatt, Dennis Health, Bilge Pakiz, Elizabeth Quintana, Loki Natarajan, Cheryl Rock
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
walnut
Overweight
Cardiovascular
Oral and gastrointestinal
Body Mass Index
0302 clinical medicine
Weight loss
Fat-Restricted
Genotype
2.1 Biological and endogenous factors
Promoter Regions
Genetic
Diet
Fat-Restricted
Cancer
2. Zero hunger
diet intervention
Nutrition and Dietetics
Brief Report
Incidence (epidemiology)
Single Nucleotide
Middle Aged
3. Good health
030220 oncology & carcinogenesis
Female
medicine.symptom
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
Clinical Trials and Supportive Activities
lcsh:TX341-641
Biology
Polymorphism
Single Nucleotide
Promoter Regions
03 medical and health sciences
Young Adult
BMI
Breast cancer
Food Sciences
Genetic
Clinical Research
Internal medicine
Weight Loss
Breast Cancer
medicine
Dietary Carbohydrates
Genetics
Humans
Obesity
Risk factor
Polymorphism
Metabolic and endocrine
Nutrition
IL-6
Interleukin-6
Prevention
medicine.disease
Dietary Fats
rs1800795
Diet
030104 developmental biology
Endocrinology
Body mass index
Biomarkers
Food Science
Zdroj: Nutrients, Vol 9, Iss 6, p 552 (2017)
Nutrients, vol 9, iss 6
Nutrients
ISSN: 2072-6643
Popis: We recently reported that interleukin-6 (IL-6), an inflammatory marker associated with breast pathology and the development of breast cancer, decreases with diet intervention and weight loss in both insulin-sensitive and insulin-resistant obese women. Here, we tested whether an individual's genotype at an IL6 SNP, rs1800795, which has previously been associated with circulating IL-6 levels, contributes to changes in IL-6 levels or modifies the effect of diet composition on IL-6 in these women. We genotyped rs1800795 in overweight/obese women (N = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality. Plasma IL-6 levels were measured at baseline, 6 and 12 months. At baseline, individuals with a CC genotype had significantly lower IL-6 levels than individuals with either a GC or GG genotype (p < 0.03; 2.72 pg/mL vs. 2.04 pg/mL), but this result was not significant when body mass index (BMI) was accounted for; the CC genotype group had lower BMI (p = 0.03; 32.5 kg/m² vs. 33.6 kg/m²). We did not observe a 2-way interaction of time*rs1800795 genotype or diet*rs1800795 genotype. Our findings provide evidence that rs1800795 is associated with IL-6 levels, but do not support a differential interaction effect of rs1800795 and diet composition or time on changes in circulating IL-6 levels. Diet intervention and weight loss are an important strategy for reducing plasma IL-6, a risk factor of breast cancer in women, regardless of their rs1800795 genotype.
Databáze: OpenAIRE
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