Comparison of three doses of leuprolide acetate in the treatment of central precocious puberty: preliminary results
| Autor: | Nancy Unanue, Karen O Klein, Juan Javier Lammoglia, Alejandra Avila, Maria Isabel Hernandez, Verónica Mericq, Germán Iñiguez, Claudio Villaroel |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Puberty Precocious law.invention Basal (phylogenetics) Endocrinology Randomized controlled trial Leuprorelin law Age Determination by Skeleton Internal medicine medicine Humans Precocious puberty Dosing Child Gonadal Steroid Hormones business.industry medicine.disease Gonadotropin secretion Treatment Outcome Female Leuprolide business medicine.drug Hormone |
| Zdroj: | Clinical Endocrinology. 71:686-690 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2009.03584.x |
| Popis: | Summary Objective Depot luteinizing-hormone releasing hormone (LHRH) agonist have been widely used for the treatment of central precocious puberty (CPP), but the optimal doses to obtain hormonal suppression are still unknown, especially in patients with higher weights. The goal of our study was to compare the efficacy of three leuprolide acetate (LA) preparations, suppressing gonadotropin secretion in patients with CPP. Design In an open 12-month protocol, we evaluated LA 7·5 mg/month, 11·25 and 22·5 every 3 months. Patients Fourteen girls with CPP and weights over 30 kg. Measurements: Clinical, radiological and laboratory follow-up: GnRH test plus LH, FSH 40 min post analogue was performed periodically. Results Pretreatment basal and LHRH stimulated LH levels between groups were not different. Basal and LHRH stimulated LH levels decreased significantly between baseline and from 3 up to 12 months of therapy in all groups (P = 0·001). GnRH stimulated LH peak |
| Databáze: | OpenAIRE |
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