Clinical usefulness of human epidermal growth factor receptor-2 extracellular domain as a biomarker for monitoring cancer status and predicting the therapeutic efficacy in breast cancer
| Autor: | Naomi Fujiwara-Honjo, Reiji Haba, Chisa Murazawa, Masahiro Ohtani, Keiichi Kontani, Hiroaki Tanaka, Yoshio Kushida, Manabu Date, Hitoshi Houchi, Shinichiro Hashimoto, Akira Yamauchi, Noriyuki Kuroda, Shoko Norimura, Hiroyasu Yokomise |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Paclitaxel Receptor ErbB-2 Population Breast Neoplasms Docetaxel Kaplan-Meier Estimate Antibodies Monoclonal Humanized Deoxycytidine Disease-Free Survival Breast cancer Trastuzumab Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Carcinoma Humans skin and connective tissue diseases education Capecitabine Aged Pharmacology education.field_of_study business.industry Carcinoma Ductal Breast Cancer Middle Aged medicine.disease Protein Structure Tertiary Treatment Outcome Drug Resistance Neoplasm Fluorouracil Clinical Study Molecular Medicine Biomarker (medicine) Female Taxoids Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Cancer Biology & Therapy. 14:20-28 |
| ISSN: | 1555-8576 1538-4047 |
| Popis: | We assessed the clinical usefulness of human epidermal growth factor receptor-2 extracellular domain (HER2ECD) as a biomarker for detecting cancer and monitoring disease status and for predicting the efficacy of anticancer treatment in breast cancer. Five-hundred and eighty serum samples from 252 patients with breast cancer were examined for the concentration of HER2ECD to compare with conventional tumor markers (CEA, CA15-3, NCC-ST439 and BCA225). Also, in 19 patients with HER2-overexpressed advanced or recurrent breast cancer who were treated with trastuzumab, clinical outcomes were evaluated retrospectively to determine whether their serum HER2ECD levels predict clinical responses. The proportion of patients with elevated HER2ECD levels was 15.1%, which was compatible with those with elevated conventional marker levels. In patients with HER2-overexpressed breast cancer, the positive rate of HER2ECD was significantly higher (24.1%) than those of conventional markers (7.4-12.9%), suggesting the usefulness of HER2ECD for detecting cancer in this population. HER2-overexpressed patients responding to trastuzumab (12 of 19 patients) showed significantly higher serum HER2ECD level (p = 0.033) and longer time to progression (TTP) (p = 0.039) and overall survival (OS) (p = 0.031) than did patients not responding (seven patients). Furthermore, higher response rates were observed in patients with elevated HER2ECD levels than in patients without elevated HER2ECD levels (91.3% vs. 14.3%, p = 0.032), whereas there was no difference in survival between the two groups. The results suggest that HER2ECD is a useful biomarker not only for detecting breast cancer recurrence but also for predicting tumor responses to trastuzumab. |
| Databáze: | OpenAIRE |
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