[S100A4, a link between metastasis and inflammation]
| Autor: | N. Ambartsumian, M. Grigorian |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biophysics Cancer Inflammation General Medicine Biology medicine.disease medicine.disease_cause Human genetics Metastasis Pathogenesis 03 medical and health sciences 0302 clinical medicine 030104 developmental biology Structural Biology Fibrosis 030220 oncology & carcinogenesis Immunology medicine medicine.symptom Carcinogenesis Function (biology) |
| Zdroj: | Molekuliarnaia biologiia. 50(4) |
| ISSN: | 0026-8984 |
| Popis: | Chronic inflammation is acknowledged to be a hallmark of neoplasia - both in cancer initiation and metastasis progression. Here we summarise data suggesting that S100A4 is а trigger of the cascade events that establish an inflammatory milieu and provide a potent flame for primary tumour growth and especially for its metastatic dissemination. The S100A4 protein belongs to the S100 superfamily of small Ca^(2+)-binding proteins. Well established function of S100A4 is associated with induction and promotion of tumour metastasis. However, this protein is also involved in the pathogenesis of major human non-communicable diseases (NCD), such as autoimmune diseases, fibrosis, and other disorders. Therefore, we suggest that S100A4 is a common pro-inflammatory factor involved in the pathogenesis of diverse NCD including cancer. |
| Databáze: | OpenAIRE |
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