A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports
| Autor: | Ali Mohammad Pourbagher-Shahri, Jan Aaseth, Saeed Samarghandian, Babak Roshanravan, Farshad Shirazi, Farhad Saeedi, Omid Mehrpour, Tahereh Farkhondeh, Emad Yeganeh Khorasani, Mohammad Abdollahi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Hematological disorders medicine.medical_specialty Adolescent medicine.medical_treatment Lead pollution India Iran Global Health Opium Opium Dependence Toxicology Risk Assessment Lead poisoning Electric Power Supplies Risk Factors Detoxification (alternative medicine) Occupational Exposure medicine Humans Child Intensive care medicine Chelating Agents Pharmacology Evidence-Based Medicine business.industry Infant Newborn Infant Environmental exposure Prognosis medicine.disease United States Medicine Ayurvedic Lead Poisoning Substance abuse Child Preschool Lead exposure Female Wounds Gunshot Occupational exposure Drug Contamination business |
| Zdroj: | Toxicology and Applied Pharmacology. 429:115681 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/j.taap.2021.115681 |
| Popis: | Lead is one of the most toxic heavy metals in the environment. The present review aimed to highlight hazardous pollution sources, management, and review symptoms of lead poisonings in various parts of the world. The present study summarized the information available from case reports and case series studies from 2009 to March 2020 on the lead pollution sources and clinical symptoms. All are along with detoxification methods in infants, children, and adults. Our literature compilation includes results from 126 studies on lead poisoning. We found that traditional medication, occupational exposure, and substance abuse are as common as previously reported sources of lead exposure for children and adults. Ayurvedic medications and gunshot wounds have been identified as the most common source of exposure in the United States. However, opium and occupational exposure to the batteries were primarily seen in Iran and India. Furthermore, neurological, gastrointestinal, and hematological disorders were the most frequently occurring symptoms in lead-poisoned patients. As for therapeutic strategies, our findings confirm the safety and efficacy of chelating agents, even for infants. Our results suggest that treatment with chelating agents combined with the prevention of environmental exposure may be an excellent strategy to reduce the rate of lead poisoning. Besides, more clinical studies and long-term follow-ups are necessary to address all questions about lead poisoning management. |
| Databáze: | OpenAIRE |
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