Role of Thiol-Disulphide Haemostasis in Early Diagnosis of Acute Mesentery Ischemia: An Experimental Study
| Autor: | Mehmet Aykut, Yıldırım, Rahim, Kocabaş, İbrahim, Kılınç, Gürcan, Şimşek, Mustafa, Şentürk, Murat, Çakır, Metin, Belviranlı |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Hemostasis Pathology medicine.medical_specialty Chemistry Ischemia Reproducibility of Results medicine.disease Oxidative Stress Early Diagnosis Anesthesiology and Pain Medicine medicine.anatomical_structure Mesenteric Ischemia Lactates Emergency Medicine Thiol medicine Humans Mesentery Surgery Disulfides Sulfhydryl Compounds Biomarkers Serum Albumin |
| Zdroj: | Turkish Journal of Trauma and Emergency Surgery. |
| ISSN: | 1306-696X |
| DOI: | 10.14744/tjtes.2020.44025 |
| Popis: | Acute mesenteric ischemia (AMI) is a rarely observed acute abdominal disease that may be mortal and is difficult to diagnose early. The aim of our study is to assess the role of Thiol-Disulphide Haemostasis (TDH), a new method for AMI which still has no specific biochemical markers for early diagnosis, and to assess it together with Ischemia-Modified Albumin (IMA) which has previously proven reliability for AMI.The study included 32 Wistar albino rats in four groups. The 1st group (n=8) was the control group, 2nd group (n=8) was the sham group, 3rd group (n=8) had 3 h of arterial mesentery ischemia and the 4th group (n=8) had 6 h of arterial mesentery ischemia. TDH, IMA, and serum lactate values were measured at h 0, 1, 3, and 6.In the 3rd and 6th h, serum total thiol and native thiol values significantly reduced (p0.001), while serum disulfide, IMA, and lactate values clearly increased (p0.001). Serum thiol values were observed to reduce from the 1st h.TDH changes in the early period of AMI. The TDH parameters can be used with IMA as diagnostic parameters for patients with suspected AMI in the early period. |
| Databáze: | OpenAIRE |
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