Radiation exposure and establishment of diagnostic reference levels of whole-body low-dose CT for the assessment of multiple myeloma with second- and third-generation dual-source CT
| Autor: | Axel Wetter, Nika Guberina, Marcel Opitz, Johannes Haubold, Michael Forsting, Sebastian Zensen, Denise Bos |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Whole body imaging Dual source ct Medizin Computed tomography Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Strahlentherapie Radiation Dosage 030218 nuclear medicine & medical imaging Radiography Dual-Energy Scanned Projection 03 medical and health sciences 0302 clinical medicine Medical imaging Diagnostic Reference Levels Medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging ddc:610 Multiple myeloma Retrospective Studies whole body imaging Modality (human–computer interaction) Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Radiation exposure computed tomography General Medicine Middle Aged Radiation Exposure medicine.disease Third generation radiation dosimetry multiple myeloma Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie 030220 oncology & carcinogenesis Female business Nuclear medicine Multiple Myeloma Tomography X-Ray Computed |
| Popis: | Background In the assessment of diseases causing skeletal lesions such as multiple myeloma (MM), whole-body low-dose computed tomography (WBLDCT) is a sensitive diagnostic imaging modality, which has the potential to replace the conventional radiographic survey. Purpose To optimize radiation protection and examine radiation exposure, and effective and organ doses of WBLDCT using different modern dual-source CT (DSCT) devices, and to establish local diagnostic reference levels (DRL). Material and Methods In this retrospective study, 281 WBLDCT scans of 232 patients performed between January 2017 and April 2020 either on a second- (A) or third-generation (B) DSCT device could be included. Radiation exposure indices and organ and effective doses were calculated using a commercially available automated dose-tracking software based on Monte-Carlo simulation techniques. Results The radiation exposure indices and effective doses were distributed as follows (median, interquartile range): (A) second-generation DSCT: volume-weighted CT dose index (CTDIvol) 1.78 mGy (1.47–2.17 mGy); dose length product (DLP) 282.8 mGy·cm (224.6–319.4 mGy·cm), effective dose (ED) 1.87 mSv (1.61–2.17 mSv) and (B) third-generation DSCT: CTDIvol 0.56 mGy (0.47–0.67 mGy), DLP 92.0 mGy·cm (73.7–107.6 mGy·cm), ED 0.61 mSv (0.52–0.69 mSv). Radiation exposure indices and effective and organ doses were significantly lower with third-generation DSCT ( P vol at 0.75 mGy and DLP at 120 mGy·cm. Conclusion Third-generation DSCT requires significantly lower radiation dose for WBLDCT than second-generation DSCT and has an effective dose below reported doses for radiographic skeletal surveys. To ensure radiation protection, DRLs regarding WBLDCT are required, where our locally determined values may help as benchmarks. |
| Databáze: | OpenAIRE |
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