Association of Hepatic Lipase -514T Allele with Coronary Artery Disease and Ankle-Brachial Index, Dependence on the Lipoprotein Phenotype: The GENES Study
| Autor: | Meyer Elbaz, Céline Verdier, Bertrand Perret, Jean Ferrières, Dorota Taraszkiewicz, Jean Bernard Ruidavets, Vanina Bongard, Laurent O. Martinez |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
lcsh:Medicine Coronary Artery Disease Cardiovascular Biochemistry Coronary artery disease Polymorphism (computer science) Risk Factors Genotype Odds Ratio lcsh:Science Multidisciplinary Middle Aged Lipids Phenotype Cardiology Medicine Research Article medicine.medical_specialty Clinical Research Design Lipoproteins Biology Polymorphism Single Nucleotide Internal medicine medicine Genetics Humans Ankle Brachial Index Genetic Predisposition to Disease cardiovascular diseases Genotyping Genetic Association Studies Alleles Aged lcsh:R Case-control study Human Genetics Odds ratio Lipase medicine.disease Lipid Metabolism Atherosclerosis Endocrinology Case-Control Studies Genetic Polymorphism lcsh:Q Hepatic lipase Population Genetics Lipoprotein |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 7, p e67805 (2013) |
| ISSN: | 1932-6203 |
| Popis: | OBJECTIVES: Relationship between hepatic lipase (LIPC) polymorphism and coronary artery disease (CAD) has often led to contradictory results. We studied this relation by genotyping rs1800588 in the LIPC promoter in a case-control study on CAD (the GENES study). We also investigated the relationship between this polymorphism and the ankle-brachial index (ABI), which is predictive of atherosclerosis progression and complications in patients at high cardiovascular risk. METHODS: 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. Medical data, clinical examination including determination of ABI and biological measurements related to cardiovascular risk factors enabled multivariate analyses and multiple adjustments. RESULTS: CAD cases showed a higher T-allele frequency than controls (0.246 vs 0.192, p = 0.003). An interaction has been found between LIPC polymorphism and triglycerides (TG) levels regarding risk of CAD: TT-homozigosity was associated with an Odds ratio (OR) of 6.4 (CI: 1.8-22.3) when TG were below 1.5 g/L, but no association was found at higher TG levels (OR = 1.34, CI: 0.3-5.9). The distribution of LIPC genotypes was compared between CAD patients with normal or abnormal ABI and impact of LIPC polymorphism on ABI was determined. Following multiple adjustments, association of the T-allele with pejorative ABI ( |
| Databáze: | OpenAIRE |
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