Cholesterol levels, atherosclerosis and liver morphology in rabbits fed cyclopropenoid fatty acids
| Autor: | D. J. Lee, R.O. Sinnhuber, T.L. Ferguson, J.H. Wales |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Liver morphology
Male medicine.medical_specialty Cholesterol Arteriosclerosis Aortic Diseases Biology Toxicology Dietary Fats Cholesterol Dietary chemistry.chemical_compound Liver cholesterol Structure-Activity Relationship Endocrinology chemistry Plasma cholesterol Liver Internal medicine medicine Fatty Acids Unsaturated Animals lipids (amino acids peptides and proteins) Rabbits Triglycerides |
| Zdroj: | Food and cosmetics toxicology. 14(1) |
| ISSN: | 0015-6264 |
| Popis: | Male New Zealand rabbits were fed diets containing either 0.27% cyclopropenoid fatty acids (CPFA) or 0.5% cholesterol or both in combination. Compared with control animals, those receiving CPFA tended to have higher plasma- and liver-cholesterol levels and a higher incidence of aortic atherosclerosis. A similar pattern was seen when animals fed cholesterol and CPFA were compared with animals fed cholesterol alone. The observed increases in liver cholesterol, plasma cholesterol and plasma triglycerides indicated a wide range of sensitivity to CPFA. Some animals had plasma-cholesterol levels eight to ten times as high as normal after feeding had continued for 3 wk, while others showed only slight changes after 5 wk. Liver cells from all CPFA-fed animals had altered morphology and often showed extensive damage. |
| Databáze: | OpenAIRE |
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