Effects of prostaglandin F2α (PGF2α) on secretion of estradiol-17β and cortisol in 90 to 100 day hysterectomized, intact and ovariectomized pregnant ewes
| Autor: | Yoshie S. Weems, K. Miller-Patrick, K.D. Nusser, C.W. Weems, Y. Tanaka, K.S. Ledgerwood, D.L. Vincent |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone Ovariectomy medicine.medical_treatment Prostaglandin Dinoprost Hysterectomy Biochemistry chemistry.chemical_compound Endocrinology Pregnancy Internal medicine In vehicle Animals Medicine Estradiol 17β Secretion Sheep Estradiol business.industry Venous blood medicine.disease chemistry Ovariectomized rat Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Prostaglandins. 48:139-156 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(94)90015-9 |
| Popis: | Vehicle or 8 or 16 mg PGF2 alpha/58 kg/body weight (BW) was given intramuscularly to intact, hysterectomized and ovariectomized 90 to 100 day pregnant ewes in three separate experiments. Hysterectomy alone decreased (Por = 0.05) estradiol-17 beta in jugular venous blood by 80 percent within 16 hours and profiles of estradiol-17 beta did not differ (Por = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. Profiles of estradiol-17 beta differed (Por = 0.05) in intact pregnant ewes treated with 8 or 16 mg PGF2 alpha/58 kg/BW when compared to controls and in ovariectomized (Por = 0.10) 90 to 100 day pregnant ewes treated with 16 mg PGF2/58 kg/BW. Estradiol-17 beta decreased (Por = 0.05) over time in vehicle and 8 mg PGF2 alpha/58 kg/BW-treated intact and in vehicle-treated ovariectomized 90 to 100 day pregnant ewes. Cortisol decreased (Por = 0.05) over time in hysterectomized, intact, and ovariectomized 90 to 100 days pregnant ewes, but did not differ (Por = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. It is suggested that estradiol-17 beta has a role in regulating ovine placental steroidogenesis. |
| Databáze: | OpenAIRE |
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