Behavioural, pharmacological, morpho-functional molecular studies reveal a hyperfunctioning mesocortical dopamine system in an animal model of attention deficit and hyperactivity disorder
| Autor: | Davide Viggiano, L.A. Ruocco, Adolfo G. Sadile, Daniela Vallone |
|---|---|
| Přispěvatelé: | Viggiano, D, Vallone, D, Ruocco, La, Sadile, Adolfo |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Dopamine Cognitive Neuroscience Prefrontal Cortex Mesolimbic pathway Receptors Dopamine Behavioral Neuroscience chemistry.chemical_compound Dopamine receptor D3 Internal medicine Neural Pathways Genetic model Limbic System medicine Animals Neurotransmitter Prefrontal cortex Dopaminergic Rats Inbred Strains Rats Ventral tegmental area Disease Models Animal Neuropsychology and Physiological Psychology Endocrinology medicine.anatomical_structure chemistry Attention Deficit Disorder with Hyperactivity Exploratory Behavior Psychology Neuroscience medicine.drug |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 27:683-689 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2003.08.011 |
| Popis: | Clinical and experimental evidence suggest an involvement of dopamine systems, mainly the mesocorticolimbic one (MCL), in Attention-Deficit Hyperactivity Disorder (ADHD). However, it remains to be ascertained whether the systems are hyper- or hypo-functioning, for the implications of the functional state. Indeed, differential functional states of the MCL branches are suggested to be the neural substrate of different ADHD variants. This review covers published and unpublished data from the Naples-High Excitability (NHE) rat, an animal model of ADHD, featuring its main aspects, with no hypertension. Therefore, a multiple approach based on morphological studies of dopamine, norepinephrine, glutamate, acetylcholine and GABA systems, synaptic (Calcium/Calmodulin kinase II) and extrasynaptic (chondroitin sulphates) environments, and molecular biology and pharmacological studies on the dopamine system has been carried out. Morphological findings suggest dopamine neurons in the Ventral Tegmental Area (VTA) to be hypertrophic in NHE rats. The mesostriatal and mesolimbic dopamine branches appear to be normal in basal conditions. However, the striatal interface is probably defective following activation. Conversely, the prefrontal cortex, which represents the second main target of VTA dopamine neurons, has many alterations at the basal level. Therefore, the emerging picture is the association of a hyperinnervating and hyperfunctioning mesocortical branch of the dopamine system. Thus, the evidence gathered so far might improve our understanding of the neural substrates of neuropsychiatric disorders such as ADHD, schizophrenia and drug addiction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect