Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study
| Autor: | Kei Funaki, Daisuke Ito, Iori Tanahashi, Takahito Yoshizaki, Hajime Tabuchi, Tadaki Nakahara, Hiroumi Shimazaki, Taisei Wake, Masahiro Jinzaki, Masaru Mimura, Haruo Yoshimasu, Bun Yamagata |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Longitudinal study Amyloid Disclosure Anxiety 03 medical and health sciences 0302 clinical medicine Alzheimer Disease mental disorders medicine Humans Cognitive Dysfunction Longitudinal Studies Cognitive decline Aged Amyloid beta-Peptides 030214 geriatrics business.industry Depression General Neuroscience medicine.disease Healthy Volunteers Psychiatry and Mental health Clinical Psychology Female Geriatrics and Gerontology Alzheimer's disease business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | American journal of Alzheimer's disease and other dementias. 35 |
| ISSN: | 1938-2731 |
| Popis: | This study aimed to investigate the long-term impacts of disclosing amyloid status for a risk of Alzheimer disease (AD) to cognitively normal research participants with subjective cognitive decline (SCD), which represents an initial manifestation of AD. Forty-two participants were classified as the amyloid-positive ( n = 10) or amyloid-negative ( n = 32) groups. We assessed symptoms of anxiety, depression, and test-related distress at 6, 24, and 52 weeks after results disclosure. No difference was found over time in anxiety, depression, and test-related distress in either group. Although no significant differences were observed between groups in anxiety or depression, the amyloid-negative group had a significantly higher level of test-related distress than the amyloid-positive group at 52 weeks. Disclosing amyloid status to cognitively healthy research participants with SCD did not cause significant long-term psychological risks. However, a theoretical spectrum of subjective concern may exist about cognitive decline in amyloid-negative individuals. |
| Databáze: | OpenAIRE |
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