Beta-adrenergic stimulation of androgen production by fetal mouse Leydig cells in primary culture
| Autor: | M.-T. Latreille, Georges Pointis |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Epinephrine medicine.drug_class Adrenergic Propranolol Biology Chorionic Gonadotropin Norepinephrine (medication) Cellular and Molecular Neuroscience Mice Norepinephrine Internal medicine 1-Methyl-3-isobutylxanthine Receptors Adrenergic beta Testis medicine Animals Molecular Biology Cells Cultured Pharmacology Fetus Leydig cell urogenital system Isoproterenol Leydig Cells Cell Biology Androgen medicine.anatomical_structure Endocrinology Cell culture Androgens Molecular Medicine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Experientia. 42(6) |
| ISSN: | 0014-4754 |
| Popis: | The responsiveness of fetal mouse Leydig cells to catecholamines (epinephrine, norepinephrine), a beta-agonist agent (L-isoproterenol) and hCG was investigated in vitro. Fetal Leydig cells when freshly isolated were unable to respond to L-isoproterenol (10(-5) M). However, L-isoproterenol, epinephrine and norepinephrine significantly stimulated androgen production by fetal Leydig cells after 24 h of primary culture. Androgen production was increased in both conditions and to a greater extent by hCG. Propranolol blocked the stimulatory effect of L-isoproterenol and epinephrine. It is concluded that catecholamines can regulate fetal testosterone biosynthesis. |
| Databáze: | OpenAIRE |
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