Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates
| Autor: | Veeral N. Tolia, Margarita Bidegain, Megan W Berube, Carolyn Pizoli, Rachel G. Greenberg, C. Michael Cotten, Monica E. Lemmon |
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| Rok vydání: | 2019 |
| Předmět: |
Inotrope
Male medicine.drug_class Sedation 03 medical and health sciences Benzodiazepines 0302 clinical medicine Hypothermia Induced 030225 pediatrics Intensive care medicine Humans Hypnotics and Sedatives 030212 general & internal medicine Hospital Mortality Prospective cohort study Benzodiazepine business.industry Infant Newborn Obstetrics and Gynecology Gestational age Hypothermia Respiration Artificial Analgesics Opioid Opioid Anesthesia Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain Anticonvulsants Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association. 40(1) |
| ISSN: | 1476-5543 |
| Popis: | To evaluate the use of sedatives and analgesics during therapeutic hypothermia in encephalopathic neonates and assess associations between medication exposure and hospital outcomes. We identified neonates ≥35 weeks gestational age treated with therapeutic hypothermia at 125 neonatal intensive care units between 2007 and 2015. We compared characteristics and hospital outcomes between unexposed neonates and neonates exposed to opioids and/or benzodiazepines. Opioids were administered to 1 677/2 621 (64%) neonates, and exposure increased from 38% in 2008 to 68% in 2015. Sedation/analgesia varied widely between centers. Opioid-exposed neonates experienced greater durations of respiratory support and were more likely to receive inotropes and inhaled nitric oxide. Mortality during postnatal days 0–3 was lower among opioid-exposed neonates (31/625 [5%]) than unexposed neonates (64/714 [9%]). Sedation/analgesia during therapeutic hypothermia is prevalent but not uniform across centers. Prospective studies are needed to assess if exposure independently predicts intensity and duration of physiologic support. |
| Databáze: | OpenAIRE |
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