An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs)
| Autor: | Hong Da Wu, Malosi Poma, Jen Chang Yang, Sheng Yang Lee, Yu Wei Wu, Tzong-Fu Kuo |
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| Rok vydání: | 2015 |
| Předmět: |
Calcium Phosphates
Materials science medicine.medical_treatment Sus scrofa Transplantation Heterologous chemistry.chemical_element Bioengineering Calcium Calcium Sulfate Biomaterials chemistry.chemical_compound X-Ray Diffraction Osteogenesis In vivo Dental pulp stem cells medicine Animals Humans Dissolution testing Amorphous calcium phosphate Sulfate Dental implant Bone regeneration Dental Pulp Bone Transplantation Stem Cells Anatomy chemistry Mechanics of Materials Microscopy Electron Scanning Stem Cell Transplantation Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 50:19-23 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2015.01.092 |
| Popis: | The purpose of this in vivo study was to evaluate the effect of human dental pulp stem cells (hDPSCs) on various resorbable calcium sulfate/calcium phosphate bone grafts in bone regeneration. Granular particles of calcium sulfate dehydrate (CSD), α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP), and CSD/β-tricalcium phosphates (β-TCP) were prepared for in vitro dissolution and implantation test. The chemical compositions of specimen residues after dissolution test were characterized by XRD. The ratios of new bone formation for implanted grafts/hDPSCs were evaluated using mandible bony defect model of Lanyu pig. All the graft systems exhibited a similar two-stage dissolution behavior and phase transformation of poor crystalline HAp. Eight weeks post-operation, the addition of hDPSCs to various graft systems showed statistically significant increasing in the ratio of new bone formation (p |
| Databáze: | OpenAIRE |
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